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Publication: J Clin Oncol

Year: 2010

Trabectedin Plus Pegylated Liposomal Doxorubicin in Recurrent Ovarian Cancer

Authors:
Monk, B.J.; Herzog, T.J.; Kaye, S.B.; Krasner, C.N.; Vermorken, J.B.; Muggia, F.M.; Pujade-Lauraine, E.; Lisyanskaya, A.S.; Makhson, A.N.; Rolski, J.; Gorbounova, V.A.; Ghatage, P.; Bidzinski, M.; Shen, K.; Nganv, H.Y-S.; Vergote, I.B.; Nam, J-H.; Park, Y.C.; Lebedinsky, C.A.; Poveda, A.M.

Publication: Curr Opin Investig Drugs

Year: 2009

The mechanism of action of plitidepsin.

Authors:
Muñoz-Alonso, M.J.; González-Santiago, L.; Martínez, T.; Losada, A.; Galmarini, C.M.; Muñoz, A.

Publication: J Clin Oncol

Year: 2009

Efficacy and Safety of Trabectedin in Patients With Advanced or Metastatic Liposarcoma or Leiomyosarcoma After Failure of Prior Anthracyclines and Ifosfamide: Results of a Randomized Phase II Study of Two Different Schedules

Authors:
Demetri, G.D.; Chawla, S.P.; von Mehren, M.; Ritch, P.; Baker, L.H.; Blay, J.Y.; Hande, K.R.; Keohan, M.L.; Samuels, B.L.; Schuetze, S.; Lebedinsky, C.; Elsayed, Y.A.; Izquierdo, M.A.; Gómez, J.; Park, Y.C.; Le Cesne, A.

Publication: Ann Oncol

Year: 2009

Phase II randomized study of trabectedin given as two different every 3 weeks dose schedules (1.5 mg/m2 24 h or 1.3 mg/m2 3 h) to patients with relapsed, platinum-sensitive, advanced ovarian cancer

Authors:
Del Campo, J.M.; Roszak, A.; Bidzinski, M.; Ciuleanu, T.E.; Hogberg, T.; Wojtukiewicz, M.Z.; Poveda, A.; Boman, K.; Westermann, A.M.; Lebedinsky, C.

Publication: Ann Oncol

Year: 2008

A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies

Authors:
von Mehren, M.; Schilder, R.J.; Cheng, J.D.; Temmer, E.; Cardoso, T.M.; Renshaw, F.G.; Bayever, E.; Zannikos, P.; Yuan, Z.; Cohen, R.B.

Oncology pipeline

PharmaMar develops and commercializes YONDELIS® in Europe and has three clinical-stage drug candidates under development for several types of solid and hematological cancers, Aplidin ®, Lurbinectedin, and PM184.

Science & Innovation

Our strong commitment to oncology translational research along with our deep understanding of the marine biodiversity of our oceans is placing us at the head of marine biotechnology.

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