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Publication: Br J Cancer

Year: 2017

Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms.

Authors:
Romano, M.; Della Porta, M.G.; Gall A.; Panini, N.; Licandro, S.A.; Bello, E.; Craparotta, I.; Rosti, V.; Bonetti, E.; Tancredi, R.; Rossi, M.; Mannarino, L.; Marchini, S.; Porcu, L.; Galmarini, C.M.; Zambelli, A.; Zecca, M.; Locatelli, F.; Cazzola, M.; Biondi, A.; Rambaldi, A.; Allavena, P.; Erba, E.; D'Incalci, M.

Publication: J Clin Oncol

Year: 2016

Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.

Authors:
Demetri, G.D.; von Mehren, M.; Jones, R.L.; Hensley, M.L.; Schuetze, S.M.; Staddon, A.; Milhem, M.; Elias, A.; Ganjoo, K.; Tawbi, H.; Van Tine, B.A.; Spira, A.; Dean, A.; Khokhar, N.Z.; Park, Y.C.; Knoblauch, R.E.; Parekh, T.V.; Maki, R.G.; Patel, S.R.

Publication: Invest New Drugs

Year: 2016

Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors.

Authors:
Paz-Ares, L.; Forster, M.; Boni, V.; Szyldergemajn, S.; Corral, J.; Turnbull, S.; Cubillo, A.; Teruel, C.F.; Calderero, I.L.; Siguero, M.; Bohan, P.; Calvo, E.

Publication: Dis Model Mech

Year: 2016

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.

Authors:
Céspedes, M.V.; Guillén, M.J.; López-Casas, P.P.; Sarno, F.; Gallardo, A.; Alamo, P.; Cuevas, C.; Hidalgo, M.; Galmarini, C.M.; Allavena, P.; Avilés, P.; Mangues, R.

Publication: Cancer Res

Year: 2016

Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus.

Authors:
Harlow, M.L.; Maloney, N.; Roland, J.; Guillén Navarro, M.J.; Easton, M.K.; Kitchen-Goosen, S.M.; Boguslawski, E.A.; Madaj, Z.B.; Johnson, B.K.; Bowman, M.J.; D'Incalci, M.; Winn, M.E.; Turner, L.; Hostetter, G.; Galmarini, C.M.; Aviles, P.M.; Grohar, P.J.

Oncology pipeline

PharmaMar develops and commercializes YONDELIS® in Europe and has three clinical-stage drug candidates under development for several types of solid and hematological cancers, Aplidin ®, Lurbinectedin, and PM184.

Science & Innovation

Our strong commitment to oncology translational research along with our deep understanding of the marine biodiversity of our oceans is placing us at the head of marine biotechnology.

Newsroom

If you need information about the company, our clinical trials, corporate images or multimedia, visit our newsroom