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Publicación: Br J Cancer

Año: 2017

Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms.

Autores:
Romano, M.; Della Porta, M.G.; Gall A.; Panini, N.; Licandro, S.A.; Bello, E.; Craparotta, I.; Rosti, V.; Bonetti, E.; Tancredi, R.; Rossi, M.; Mannarino, L.; Marchini, S.; Porcu, L.; Galmarini, C.M.; Zambelli, A.; Zecca, M.; Locatelli, F.; Cazzola, M.; Biondi, A.; Rambaldi, A.; Allavena, P.; Erba, E.; D'Incalci, M.

Publicación: J Clin Oncol

Año: 2016

Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.

Autores:
Demetri, G.D.; von Mehren, M.; Jones, R.L.; Hensley, M.L.; Schuetze, S.M.; Staddon, A.; Milhem, M.; Elias, A.; Ganjoo, K.; Tawbi, H.; Van Tine, B.A.; Spira, A.; Dean, A.; Khokhar, N.Z.; Park, Y.C.; Knoblauch, R.E.; Parekh, T.V.; Maki, R.G.; Patel, S.R.

Publicación: Invest New Drugs

Año: 2016

Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors.

Autores:
Paz-Ares, L.; Forster, M.; Boni, V.; Szyldergemajn, S.; Corral, J.; Turnbull, S.; Cubillo, A.; Teruel, C.F.; Calderero, I.L.; Siguero, M.; Bohan, P.; Calvo, E.

Publicación: Dis Model Mech

Año: 2016

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.

Autores:
Céspedes, M.V.; Guillén, M.J.; López-Casas, P.P.; Sarno, F.; Gallardo, A.; Alamo, P.; Cuevas, C.; Hidalgo, M.; Galmarini, C.M.; Allavena, P.; Avilés, P.; Mangues, R.

Publicación: Cancer Res

Año: 2016

Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus.

Autores:
Harlow, M.L.; Maloney, N.; Roland, J.; Guillén Navarro, M.J.; Easton, M.K.; Kitchen-Goosen, S.M.; Boguslawski, E.A.; Madaj, Z.B.; Johnson, B.K.; Bowman, M.J.; D'Incalci, M.; Winn, M.E.; Turner, L.; Hostetter, G.; Galmarini, C.M.; Aviles, P.M.; Grohar, P.J.

Productos de Oncología

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