Yondelis^®

(trabectedin)

Yondelis® (trabectedin) also referred as ET-743 during its development, is a marine derived antitumoral agent discovered in the colonial tunicate Ecteinascidia turbinata and now produced synthetically. Yondelis has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery.

Yondelis® has received Authorization for Commercialization from the European Commission for advanced soft tissue sarcoma, after failure of anthracyclines and ifosfamide, or who are unsuited to receive these agents. Other Phase II trials with Yondelis include breast, prostate, and paediatric sarcomas. Yondelis has been granted Orphan Drug designation from the European Commission (EC) and the US Food & Drug Administration (FDA) for Soft Tissue Sarcomas and Ovarian Cancer.

Yondelis® is currently being developed by PharmaMar in partnership with Johnson & Johnson Pharmaceutical Research & Development (J&JPRD). Once marketing Authorization is granted by the E.C, PharmaMar will market Yondelis in Europe (including Eastern Europe) while Ortho Biotech Products, L.P. will market it in the U.S. and the rest of the world.

If you are a doctor or a hospital pharmacist, please contact the following numbers for enquiries about Yondelis®:

Spain:
IDIS Pharma
Phone: +34 93 344 32 24
Fax: +34 93 344 32 99

United Kingdom & Ireland:
E-mail: enquiries@idispharma.com
Phone: +44 (0)1932 824100
Fax: +44 (0)1932 824300

France, Belgium y Luxembourg:
E-mail: internationalsales@idispharma.com
Phone: +33 155 273932
Fax: +33 155 273700

Germany, Switzerland, Austria and Holland:
E-mail: internationalsales@idispharma.com
Phone: +49 (0)89970 07409
Fax: +49 (0)89970 07200

Greece & Cyprus:
Genesis Pharma, S.A
274, Kfissias Avenue
Halandri, GR-152
Athens Greece
www.genesispharma.com
E-mail: info@genesispharma.com
Phone: +302108771500
Fax: +302106896619

Sweden, Norway, Denmark, Finland, Iceland, Latvia, Lithuania, Estonia, Czech Republic, Poland, Slovakia, Slovenia, Hungary, Romania, Bulgaria:
Swedish Orphan
Phone: +46 (0)8 412 98 00
Fax: +46 (0)8 412 98 99
www.swedishorphan.com

Other territories:
E-mail: internationalsales@idispharma.com
Phone: +44 (0)1932 824123
Fax: +44 (0)1932 824323